What question did this study set out to answer?

To determine whether cardiopulmonary bypass stimulates circulating leukocyte-platelet adhesion mediated by platelet surface granule membrane protein-140 expression.

March 1, 1992BloodOpen Access

Cardiopulmonary bypass induces leukocyte-platelet adhesion

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CRCS RinderYale New Haven Hospital JBJL BonanYale University HRHM RinderYale University

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Implication

Clinical study demonstrates increased leukocyte-platelet conjugates in bypass patients, indicating distinct activation pathways for monocytes and neutrophils.

Key Points

To determine whether cardiopulmonary bypass stimulates circulating leukocyte-platelet adhesion mediated by platelet surface granule membrane protein-140 expression.
Evaluated 17 patients undergoing cardiopulmonary bypass (CPB).
Measured percentages of circulating leukocyte-platelet conjugates and cell-surface activation markers (GMP-140 and CD11b) across surgery using a whole blood assay.
Monocyte-platelet conjugates increased from 18% ± 1.5% at baseline to 44% ± 4.5% (mean ± SEM) by the end of CPB, whereas lymphocyte-platelet conjugates decreased.
Increases in monocyte- and neutrophil-platelet conjugates closely paralleled the time course of circulating activated platelets expressing surface GMP-140.
Monocyte CD11b expression rose gradually alongside conjugate formation, whereas neutrophil CD11b expression peaked immediately after the initiation of CPB.

Cite This Study

Rinder et al. (1992) studied this question.

synapsesocial.com/papers/69f3ee8cdc238f819779986f https://doi.org/10.1182/blood.v79.5.1201.1201

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Implication

Clinical study demonstrates increased leukocyte-platelet conjugates in bypass patients, indicating distinct activation pathways for monocytes and neutrophils.

Cardiopulmonary bypass induces leukocyte-platelet adhesion

Discussion

Member takes

Implication

Key Points

Cite This Study

Cardiopulmonary bypass induces leukocyte-platelet adhesion

Discussion

Member takes

Implication

Key Points

Cite This Study

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