Key result
Methylpentynol depressed autonomic reactions to a difficult motor task and impaired performance in humans, demonstrating a different mode of action compared to hexobarbitone.
Why the study?
Does methylpentynol depress autonomic reactions and impair performance in human subjects compared to hexobarbitone?
Does methylpentynol depress autonomic reactions and impair performance in human subjects compared to hexobarbitone?
Methylpentynol and hexobarbitone exhibit different modes of action regarding autonomic reactions and motor performance.
Methylpentynol may selectively impair autonomic function and performance; hypothesis-generating for distinct modes of action versus hexobarbitone and leaves clinical relevance open.
Administration of methylpentynol to human subjects depressed their autonomic reactions to a difficult motor task and impaired their performance. Hexobarbitone affected neither autonomic reactions nor performance, though it impaired hand steadiness. The results suggest that the modes of action of methylpentynol and of hexobarbitone are different.
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Dicker et al. (1957) studied this question. Methylpentynol depressed autonomic reactions to a difficult motor task and impaired performance in humans, demonstrating a different mode of action compared to hexobarbitone.
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