Key result
In 12 dogs, significant hemorrhage reducing cardiac output by half produced only a small decrease in mean regional lung density from 0.33 to 0.30 g/ml, while doubling tidal volume caused no change.
Why the study?
Do changes in tidal volume, PEEP, or blood volume significantly alter regional lung density measured by PET in dogs?
Do changes in tidal volume, PEEP, or blood volume significantly alter regional lung density measured by PET in dogs?
Changes in tidal volume, modest PEEP, and significant decreases in blood volume produce only small decreases in regional lung density, suggesting normalization of PET emission data with transmission-derived measurements may not be necessary for interventions causing rLD to decrease.
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Schuster et al. (1986) studied this question. Changes in inflation and blood volume (hemorrhage, PEEP, tidal volume) vs. Baseline was evaluated on Regional lung density (rLD). In 12 dogs, significant hemorrhage reducing cardiac output by half produced only a small decrease in mean regional lung density from 0.33 to 0.30 g/ml, while doubling tidal volume caused no change.
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