Key result
Circulating dopamine participates in the general sympathetic response only during maximal adrenal activation, such as hypoglycemia, where it increased by 62 pg/ml (P<0.025).
Why the study?
Does physiological stress or severe brain injury alter circulating dopamine levels compared to baseline in humans?
Observational (n=58)
Does physiological stress or severe brain injury alter circulating dopamine levels compared to baseline in humans?
Circulating dopamine participates in the general sympathetic response only when the adrenal component is maximally activated, such as during hypoglycemia.
No takes yet. Share an insight, caveat, or question.
Plasma DA does not track acute sympathetic activation; leaves open its clinical or research utility in stress assessment.
Woolf et al. (1983) conducted an observational in Healthy volunteers and severe brain injury (n=58). Physiological stress (upright posture, cold pressor, hypoglycemia, brain injury) vs. Basal levels was evaluated on Changes in peripheral dopamine concentrations. Circulating dopamine participates in the general sympathetic response only during maximal adrenal activation, such as hypoglycemia, where it increased by 62 pg/ml (P<0.025).
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