Neuronal Source of Plasma Dopamine
Why the study?
Does plasma dopamine originate from corelease with norepinephrine during exocytosis from sympathetic noradrenergic nerves in humans?
Population
Patients referred for autonomic testing and control subjects, including groups with pure autonomic failure…
Comparison
Experimental conditions altering exocytotic… vs Supine rest
Design
Cohort
Authors
Discussion
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Member takes
Implication
Supports sympathetic dopamine corelease with norepinephrine; hypothesis-generating for autonomic catecholamine assessment pending interventional confirmation.
Structured PICO
Does plasma dopamine originate from corelease with norepinephrine during exocytosis from sympathetic noradrenergic nerves in humans?
P
Population
Patients referred for autonomic testing and control subjects, including groups with pure autonomic failure (PAF), bilateral thoracic sympathectomies (SNS-x), or multiple system atrophy (MSA)
I
Intervention
Experimental conditions altering exocytotic release of norepinephrine: orthostasis, intravenous yohimbine (YOH), isoproterenol (ISO), glucagon (GLU), trimethaphan (TRI), pentolinium (PEN), or tyramine (TYR)
C
Comparator
Supine rest
O
Outcome
Changes in plasma dopamine concentrations and their correlation with changes in norepinephrinesurrogate
Plasma dopamine is derived substantially from sympathetic noradrenergic nerves, where it is coreleased with norepinephrine during exocytosis.
Cite This Study
Goldstein et al. (2008) studied this question.