Key result
Reduced IGFBP-1 levels and increased IGF-II levels correlated with increased cardiovascular risk factors, including total and LDL cholesterol, in patients with NIDDM.
Why the study?
Do IGF-I, IGF-II, and IGFBP-1 levels correlate with cardiovascular risk factors in patients with NIDDM?
Observational (n=74)
Do IGF-I, IGF-II, and IGFBP-1 levels correlate with cardiovascular risk factors in patients with NIDDM?
Effect estimate: 0.72
In patients with NIDDM, IGF-II levels correlate positively with atherogenic lipids like total and LDL cholesterol, suggesting a potential role in macrovascular risk.
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IGF-II-lipid links in NIDDM need prospective validation; leaves open any causal role in macrovascular disease.
Martin Gibson (1996) conducted an observational in Non-insulin dependent diabetes mellitus (NIDDM) (n=74). IGF-I, IGF-II, and IGFBP-1 levels was evaluated on Correlation with cardiovascular risk factors (total and LDL cholesterol) (0.72). Reduced IGFBP-1 levels and increased IGF-II levels correlated with increased cardiovascular risk factors, including total and LDL cholesterol, in patients with NIDDM.
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