Key result
Sympathetic nerve stimulation in infarcted rat hearts evoked ventricular premature beats (95%), tachycardia (37%), and fibrillation (26%), whereas arrhythmias were rare at baseline.
Why the study?
Does sympathetic activation trigger ventricular arrhythmias in a rat model of chronic infarction and heart failure?
Does sympathetic activation trigger ventricular arrhythmias in a rat model of chronic infarction and heart failure?
Sympathetic activation directly triggers ventricular tachyarrhythmias in a rat model of chronic myocardial infarction and heart failure, with inducibility dependent on infarct size and stimulation frequency.
Authors
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May warrant caution in sympathetic modulation post-MI; leaves open causal translation from rat models to humans.
Xuan Du (1999) studied Chronic myocardial infarction and heart failure. Sympathetic nerve stimulation vs. Baseline / sham operation was evaluated on Inducibility of ventricular arrhythmias. Sympathetic nerve stimulation in infarcted rat hearts evoked ventricular premature beats (95%), tachycardia (37%), and fibrillation (26%), whereas arrhythmias were rare at baseline.
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