Key result
Orthotopic heart transplantation in a patient with Marfan syndrome was complicated by late-onset type B aortic dissection requiring open thoracoabdominal aortic repair 6 months post-transplant.
Case Report (n=1)
Heart transplantation in Marfan syndrome patients can trigger late-onset type B aortic dissection even in mildly dilated aortas, requiring careful monitoring and potential surgical repair.
Successful heart transplant in Marfan syndrome with late type B dissection; leaves open optimal post-transplant aortic surveillance.
Heart transplantation in patients with Marfan syndrome is challenging and raises concerns with regards to the haemodynamic and immunosuppressive-induced effects on the inherently fragile aorta. Most aortic events following transplantation reported so far in the literature occurred in patients with pre-existent distal aortic dissection. We report a case of successful orthotopic heart transplantation in a patient with Marfan syndrome that was complicated by late-onset type B dissection in pre-existing mild and stable distal aortic dilation. Serial aortic imaging revealed progressive growth at the level of the descending thoracic aorta. An open thoracoabdominal aortic repair procedure was successfully performed 6 months after the transplantation.
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Audenaert et al. (2015) conducted a case report in Marfan syndrome and heart transplantation (n=1). Orthotopic heart transplantation was evaluated on Development of type B aortic dissection and subsequent repair. Orthotopic heart transplantation in a patient with Marfan syndrome was complicated by late-onset type B aortic dissection requiring open thoracoabdominal aortic repair 6 months post-transplant.
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