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June 28, 2004Exercise and Sport Sciences Reviews

Exercise Training and Sympathetic Regulation in Experimental Heart Failure

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Why the study?

Does exercise training reduce sympathetic outflow in animals with experimental heart failure?

Population

Animals with experimental heart failure

Design

Review

Key result

Exercise training in experimental heart failure reduces sympathetic nerve activity through a central mechanism involving angiotensin II and nitric oxide.

Authors

IZIrving H. ZuckerKPKaushik P. PatelHSHarold D. Schultz

Discussion

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Member takes

Overview

May attenuate sympathetic outflow in experimental HF via Ang II/AT1 reduction; leaves open clinical translation and direct mechanistic confirmation.

Structured PICO

Does exercise training reduce sympathetic outflow in animals with experimental heart failure?

P
Population
Animals with experimental heart failure
I
Intervention
Exercise training
O
Outcome
Sympathetic nerve activity / sympathetic outflowsurrogate

Exercise training reduces sympathetic nerve activity in experimental heart failure via central mechanisms involving angiotensin II and nitric oxide.

Cite This Study

Zucker et al. (2004) conducted a review in Heart failure. Exercise training was evaluated on Sympathetic nerve activity. Exercise training in experimental heart failure reduces sympathetic nerve activity through a central mechanism involving angiotensin II and nitric oxide.

synapsesocial.com/papers/6a657adcef090507bbf0cd95https://doi.org/10.1097/00003677-200407000-00006
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Controlled trial of physical training in chronic heart failure. Exercise performance, hemodynamics, ventilation, and autonomic function.1992 · 955 citations
  2. 2Enhanced neuronal nitric oxide synthase expression is central to cardiac vagal phenotype in exercise‐trained mice2003 · 73 citations
  3. 3Enhanced peripheral chemoreflex function in conscious rabbits with pacing-induced heart failure1999 · 186 citations
  4. 4Amelioration of depressed cardiopulmonary reflex control of sympathetic nerve activity by short-term exercise training in male rabbits with heart failure2003 · 47 citations
  5. 5Exercise training enhances baroreflex control of heart rate by a vagal mechanism in rabbits with heart failure2002 · 74 citations