Weight loss through a hypocaloric diet with or without exercise training significantly decreased resting muscle sympathetic nerve activity and improved muscle metaboreflex control in obese women.
Cohort (n=59)
Does weight loss via hypocaloric diet with or without exercise improve neurovascular and muscle metaboreflex control in normotensive obese women?
Weight loss through diet and exercise improves muscle metaboreflex control and increases forearm vascular conductance in obese women.
We studied the effects of a hypocaloric diet (D, n = 24, age: 32.2 +/- 1.4 yr, body mass index: 34.7 +/- 0.5 kg/m2) and a hypocaloric diet associated with exercise training (D + T, n = 25, age: 32.3 +/- 1.3 yr, body mass index: 32.9 +/- 0.4 kg/m2) on muscle metaboreflex control, muscle sympathetic nerve activity (MSNA, microneurography), blood pressure, and forearm blood flow (plethysmography) levels during handgrip exercise at 10% and 30% of maximal voluntary contraction in normotensive obese women. An additional 10 women matched by age and body mass index were studied as a nonadherent group. D or D + T significantly decreased body mass index. D or D + T significantly decreased resting MSNA (bursts/100 heartbeats). The absolute levels of MSNA were significantly lower throughout 10% and 30% exercise after D or D + T, although no change was found in the magnitude of response of MSNA. D + T, but not D, significantly increased resting forearm vascular conductance. D + T significantly increased the magnitude of the response of forearm vascular conductance during 30% exercise. D or D + T significantly increased MSNA levels during posthandgrip circulatory arrest when muscle metaboreflex is isolated. In conclusion, weight loss improves muscle metaboreflex control in obese women. Weight loss reduces MSNA, which seems to be centrally mediated. Weight loss by D + T increases forearm vascular conductance at rest and during exercise in obese individuals.
Trombetta et al. (Mon,) conducted a cohort in Obesity (n=59). Hypocaloric diet with or without exercise training vs. Nonadherent group was evaluated on Muscle metaboreflex control, muscle sympathetic nerve activity (MSNA), blood pressure, and forearm blood flow. Weight loss through a hypocaloric diet with or without exercise training significantly decreased resting muscle sympathetic nerve activity and improved muscle metaboreflex control in obese women.