Key result
Single mitral valve replacement in 30 patients with severe pulmonary hypertension yielded mortality similar to the general cohort and reduced mean pulmonary artery pressure to 41.5% of baseline.
Why the study?
Does single mitral valve replacement with prosthetic valves improve hemodynamics and have acceptable mortality in patients with severe preoperative pulmonary hypertension?
Population
n=30 patients with severe preoperative pulmonary hypertension undergoing single mitral valve replacement.
Comparison
Single mitral valve replacement with prosthetic… vs Total series of mitral valve replacements…
Design
Cohort
Follow-up
mean survival time 5 1/2 years (for survivors)
Authors
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Mitral valve replacement in severe pulmonary hypertension shows no excess mortality with marked improvement; leaves open applicability to contemporary practice.
Cohort (n=30)
Does single mitral valve replacement with prosthetic valves improve hemodynamics and have acceptable mortality in patients with severe preoperative pulmonary hypertension?
Severe pulmonary hypertension is not a contraindication to mitral valve replacement, as it yields comparable mortality to general mitral valve replacement patients and provides significant hemodynamic improvement.
Kaul et al. (1976) conducted a cohort in Severe pulmonary hypertension requiring mitral valve replacement (n=30). Single mitral valve replacement with prosthetic valves vs. Total series of mitral valve replacements performed over the same period was evaluated on Early and late mortality and haemodynamic improvement. Single mitral valve replacement in 30 patients with severe pulmonary hypertension yielded mortality similar to the general cohort and reduced mean pulmonary artery pressure to 41.5% of baseline.
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