Key result
In vivo AT2 receptor stimulation increased the c-kit+AT2+ cell population in the infarcted myocardium and reduced apoptosis of cardiomyocytes in rats with acute myocardial infarction.
Population
Rats with acute myocardial infarction and adult cardiomyocytes/cardiac c-kit+AT2+ cells isolated from…
Design
Preclinical
Authors
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Hypothesis-generating for AT2-mediated repair in ischemic injury; leaves open translation beyond rodent models.
AT2 receptor activation increases the cardiac c-kit+AT2+ cell population and reduces cardiomyocyte apoptosis following acute ischemic injury in a rat model.
Altarche‐Xifró et al. (2009) studied Acute myocardial infarction. AT2 receptor stimulation was evaluated on Apoptosis of cardiomyocytes and c-kit+AT2+ cell population. In vivo AT2 receptor stimulation increased the c-kit+AT2+ cell population in the infarcted myocardium and reduced apoptosis of cardiomyocytes in rats with acute myocardial infarction.
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