Key result
Long-term treatment with amlodipine/valsartan 5/320 mg once daily achieved persistent reductions in mean sitting diastolic and systolic blood pressure of 17.0 and 24.2 mmHg, respectively.
Why the study?
Does amlodipine/valsartan 5/320 mg once daily improve blood pressure in patients with mild-to-moderate essential hypertension?
Population
403 patients with mild-to-moderate essential hypertension who successfully completed a core study
Design
Cohort, open-label
Follow-up
54 weeks
Authors
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Supports sustained BP lowering with amlodipine/valsartan in mild hypertension; leaves open need for randomized confirmation before practice change.
Does amlodipine/valsartan 5/320 mg once daily improve blood pressure in patients with mild-to-moderate essential hypertension?
Long-term treatment with amlodipine/valsartan 5/320 mg once daily is well-tolerated and provides persistent reductions in blood pressure in patients with mild-to-moderate essential hypertension.
Philipp et al. (2008) studied mild-to-moderate essential hypertension (n=403). amlodipine/valsartan was evaluated on change from core study baseline in MSDBP and MSSBP at study (extension) endpoint. Long-term treatment with amlodipine/valsartan 5/320 mg once daily achieved persistent reductions in mean sitting diastolic and systolic blood pressure of 17.0 and 24.2 mmHg, respectively.
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