Key result
Nebivolol was slightly more effective than lisinopril in reducing diastolic blood pressure over 12 weeks (P=0.016 for treatment-weeks interaction), with both being equally well tolerated.
Why the study?
Does nebivolol reduce blood pressure more effectively than lisinopril in patients with mild to moderate essential hypertension?
Population
n=68 patients with uncomplicated mild-to-moderate essential hypertension, age 24-65 years, newly diagnosed…
Comparison
Nebivolol 5 mg once daily for 12 weeks vs Lisinopril 20 mg once daily for 12 weeks
Design
RCT, randomized, parallel group, double-blind
Follow-up
12 weeks
Authors
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Nebivolol yields modestly greater DBP reduction than lisinopril; extends evidence for its use as an alternative in mild-moderate hypertension.
RCT (n=68)
Double-blind
randomized
Yes
Does nebivolol reduce blood pressure more effectively than lisinopril in patients with mild to moderate essential hypertension?
p-value: p=0.016
Nebivolol 5 mg daily provides comparable antihypertensive efficacy and tolerability to lisinopril 20 mg daily in patients with mild-to-moderate essential hypertension.
Rosei et al. (2003) conducted an RCT in mild to moderate essential hypertension (n=68). Nebivolol vs. Lisinopril (20 mg once daily) was evaluated on Response rate (blood pressure <140/90 mmHg or reduction ≥10 mmHg) and changes in sitting blood pressure at the end of the study (p=0.016). Nebivolol was slightly more effective than lisinopril in reducing diastolic blood pressure over 12 weeks (P=0.016 for treatment-weeks interaction), with both being equally well tolerated.
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