Why the study?
Does lisinopril reduce blood pressure compared to metoprolol in patients with moderate to severe hypertension?
Does lisinopril reduce blood pressure compared to metoprolol in patients with moderate to severe hypertension?
Lisinopril 40-80 mg once daily is as effective as metoprolol 100-200 mg once daily in reducing diastolic blood pressure, with a greater reduction in systolic blood pressure in patients with moderate to severe hypertension.
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Supports preferring lisinopril over metoprolol for systolic control in moderate-severe hypertension; extends head-to-head RCT data on ACEI versus beta-blocker efficacy.
Zachariah et al. (1987) studied this question.
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