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July 26, 2026Scientific ReportsOpen Access

Elevated TyG index linked to ~70% higher all-cause and cardiac mortality in PCI patients.

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Why the study?

Evidence regarding the predictive ability of the triglyceride-glucose index for all-cause and cardiac mortality in patients with CHD after PCI remains limited.

Does an elevated triglyceride-glucose (TyG) index predict all-cause and cardiac mortality in patients with coronary heart disease undergoing PCI?

Population

2,533 CHD patients who underwent PCI

Comparison

Higher vs lower TyG levels

Design

Secondary analysis using data from the Dryad database

Key result

An elevated Triglyceride-glucose (TyG) index was independently associated with an increased risk of all-cause mortality (OR 1.7) and cardiac mortality in patients with coronary heart disease undergoing percutaneous coronary intervention.

Authors

XWXin WanYSY ShiRZRuigui Zheng

Discussion

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Overview

TyG index may aid post-PCI mortality risk stratification; leaves open need for prospective validation before clinical adoption.

Key Points

  • The study aims to investigate the association between the triglyceride-glucose index and mortality risk in patients with coronary heart disease following percutaneous coronary intervention.
  • Analyzed data from 2,533 coronary heart disease patients who underwent PCI using the Dryad database
  • Conducted smooth curve analysis to assess correlation between TyG levels and mortality
  • Performed ROC analysis to evaluate predictive value of the TyG index combined with other factors
  • 120 (7.2%) patients died from any cause, with 80 (4.8%) attributed to cardiac causes
  • Higher TyG levels were independently associated with increased risk of all-cause mortality (OR 1.7, 95% CI 1.1–2.7) and cardiac mortality (OR 1.7, 95% CI 1.0–3.0)
  • ROC analysis indicated a predictive value for all-cause (AUC = 0.718) and cardiac mortality (AUC = 0.697) by combining TyG with age, sex, and smoking

Study Design

Type

Cohort (n=2,533)

Multicenter

No

Structured PICO

Does an elevated triglyceride-glucose (TyG) index predict all-cause and cardiac mortality in patients with coronary heart disease undergoing PCI?

P
Population
2,533 patients with coronary heart disease who underwent percutaneous coronary intervention with drug-eluting stents, followed for a median of 29.8 months.
E
Exposure
Elevated triglyceride-glucose (TyG) index
C
Comparator
Lower triglyceride-glucose (TyG) index
O
Outcome
All-cause and cardiac mortalityhard clinical

Main Result

Odds Ratio: 1.7 (95% CI 1.1–2.7)

p-value: p=0.030

An elevated triglyceride-glucose index is independently associated with an increased risk of all-cause and cardiac mortality in patients with coronary heart disease following PCI.

Limitations

  • Retrospective, single-center study design limits causal inference
  • TyG index was calculated only once at admission, so fluctuations during follow-up were unknown
  • No adjustments were made for lipid-lowering and hypoglycemic drugs
  • Exact causes of cardiac death were unclear
  • TyG index alone had poor discriminative performance (low AUC) as a standalone predictor
  • Missing clinical parameters such as left ventricular function and detailed angiographic severity due to retrospective design

Cite This Study

Wan et al. (2026) conducted a cohort in Coronary heart disease (CHD) following percutaneous coronary intervention (PCI) (n=2,533). Elevated Triglyceride-glucose (TyG) index vs. Lower Triglyceride-glucose (TyG) index was evaluated on All-cause death (OR 1.7, 95% CI 1.1-2.7, p=0.030). An elevated Triglyceride-glucose (TyG) index was independently associated with an increased risk of all-cause mortality (OR 1.7) and cardiac mortality in patients with coronary heart disease undergoing percutaneous coronary intervention.

synapsesocial.com/papers/6a65a36cd3aea3239cd76815https://doi.org/10.1038/s41598-026-62517-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Triglyceride glucose index in patients with acute coronary syndrome undergoing percutaneous coronary intervention predicts cardiovascular events: a cohort study2025 · 5 citations
  2. 2Association between TyG index and long-term prognosis of patients with ST-segment elevated myocardial infarction undergoing percutaneous coronary intervention: a retrospective cohort study2024 · 5 citations
  3. 3Predictive value of the triglyceride-glucose index for short- and long-term all-cause mortality in patients with critical coronary artery disease: a cohort study from the MIMIC-IV database2024 · 13 citations
  4. 4Correlation of triglyceride glucose index with all cause mortality in acute myocardial infarction patients following percutaneous coronary intervention2025 · 2 citations
  5. 5Triglyceride-Glucose Index’s Link to Cardiovascular Outcomes Post-Percutaneous Coronary Intervention in China: A Meta-Analysis2024 · 24 citations