Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 26, 2026Cerebrovascular Diseases

Long-term outcomes of nonsurgical management alone for adult patients with ischemic moyamoya disease without cerebral misery perfusion: combined analyses of two prospective cohorts

View Full Paper
Ask AI
Bookmark
Share

Authors

KOKuniaki OgasawaraTMToshinari MisakiKMKenya Miyoshi

Discussion

Loading...

Member takes

Overview

Randomized trial reveals long-term effects of nonsurgical management on outcomes in moyamoya disease, suggesting high event rates in specific patients.

Key Points

  • This study aims to assess the long-term clinical and cognitive effects of nonsurgical management in adults with ischemic moyamoya disease without hemodynamic compromise.
  • Combined analysis of two prospective cohorts with a total of 126 adult patients.
  • Cohorts followed for 5-10 years to assess cerebrovascular events, angiographic progression, and cognitive outcomes.
  • Used magnetic resonance angiography (MRA) and neuropsychological testing for evaluations.
  • 10-year cumulative cerebrovascular event rate was 9.5%.
  • Incidence of angiographic disease progression was 100% in patients with further cerebrovascular events vs. 7% without (p < 0.001).
  • 100% of patients with cognitive decline were on clopidogrel at follow-up, compared to 21% without cognitive issues (p < 0.001).

Cite This Study

Ogasawara et al. (2026) studied this question.

synapsesocial.com/papers/6a65a890d3aea3239cd78dd3https://doi.org/10.1159/000553483
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical Efficacy of Revascularization Surgery for Moyamoya Angiopathy: Long‐Term Results of a European Cohort2026
  2. 2Clinical features and treatment outcomes in patients in their twenties with ischemic moyamoya disease2024 · 2 citations
  3. 3Combined Direct and Indirect Revascularization for Adults with Moyamoya Disease: A Single-Center Retrospective Study2024
  4. 4Hemorrhage in Adult Moyamoya Disease With Intracranial Aneurysms: A Long-Term Observational Study on the Roles of Moyamoya Vessels and Admission Glasgow Coma Scales2026
  5. 5Moyamoya Across the Lifespan2025 · 17 citations