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July 26, 2026Pediatric CardiologyOpen Access

Postoperative Hematocrit and Lactate Trajectory After Neonatal Cardiopulmonary Bypass: A Retrospective Cohort Study

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Authors

MRMatee U. RehmanMWM WhitehornDTDara Torgerson

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Overview

Retrospective cohort study finds higher hematocrit not associated with delayed lactate clearance in neonates, suggesting caution in transfusions.

Key Points

  • Investigate the relationship between initial postoperative hematocrit and lactate clearance following neonatal cardiac surgery.
  • Retrospective cohort study of 201 neonates requiring cardiopulmonary bypass (CPB)
  • Clinical data extracted from electronic health records (EHR) using standardized definitions
  • Multivariable linear regression and linear mixed-effects models assessed outcomes.
  • Each 10% increase in hematocrit correlated with 0.40 mmol/L higher lactate at 1 hour (95% CI 0.03-0.80; p=0.03)
  • Initial hematocrit not linked with lactate trajectories without adjustments, but associated after adjusting for time-varying factors (β = 0.29, 95% CI 0.03-0.55; p=0.03)
  • Higher initial hematocrit does not guarantee improved lactate clearance, emphasizing the need for cautious transfusion strategies.

Cite This Study

Rehman et al. (2026) studied this question.

synapsesocial.com/papers/6a65a91fd3aea3239cd79177https://doi.org/10.1007/s00246-026-04399-6
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Also Consider

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  1. 1Serum lactate clearance as a predictor of outcome in infants' postcardiac surgery2022
  2. 2The role of blood lactate clearance as a predictor of mortality in children undergoing surgery for tetralogy of Fallot2016 · 25 citations
  3. 3The Effect of Serum Lactate and Lactate Clearence on Mortality in Cardiac Surgery Patients2019 · 2 citations
  4. 4Postoperative Blood Pressure Does Not Affect Lactate Clearance in Cardiac Surgery: A Retrospective Observational Cohort Study2025
  5. 5The safe hematocrit threshold during cardiopulmonary bypass in children with cyanotic congenital heart disease: a retrospective study2025