Key result
Thrombotest and Simplastin A did not differ in their ability to detect prolonged clotting times of whole blood or plasma during dicumarol therapy.
Why the study?
Does Thrombotest differ from Simplastin A in detecting prolonged clotting times in patients on dicumarol therapy?
Cross-Sectional
Does Thrombotest differ from Simplastin A in detecting prolonged clotting times in patients on dicumarol therapy?
Thrombotest and Simplastin A perform similarly in detecting prolonged clotting times during dicumarol therapy, despite differences in sensitivity to the inhibitor.
Supports equivalent use of either test for dicumarol monitoring; leaves open performance differences in other settings or populations.
Methods used to control dicumarol therapy differ in their sensitivity to the inhibitor formed during administration of dicumarol. For this reason the therapeutic levels vary, even when the methods are standardized with the same dilutions of normal plasma. The problem investigated is whether prolonged clotting times of whole blood or plasma are heralded equally well by Thrombotest, which is sensitive to the inhibitor, as by Simplastin A (a modified P & P method), which is insensitive to it. Whole blood clotting time was determined for 130 patients, recalcification time of plasma in silicone‐treated tubes for 176 patients, and activated partial thromboplastin time for 350 patients. Thrombotest and Simplastin A were carried out simultaneously with the other tests on every patient treated with dicumarol. Thrombotest and Simplastin A did not differ in their ability to warn against prolonged clotting times of whole blood or plasma.
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K Korsan-Bengtsen (1971) conducted a cross-sectional in Anticoagulant therapy (dicumarol). Thrombotest vs. Simplastin A was evaluated on Detection of prolonged clotting times of whole blood or plasma. Thrombotest and Simplastin A did not differ in their ability to detect prolonged clotting times of whole blood or plasma during dicumarol therapy.
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