Key result
Pentavalent rotavirus vaccination provided 83% to 86% overall 3-dose effectiveness against severe rotavirus gastroenteritis, with sustained protection during the second year of life.
Why the study?
Does pentavalent rotavirus vaccination prevent severe rotavirus gastroenteritis in children?
Observational
No
Does pentavalent rotavirus vaccination prevent severe rotavirus gastroenteritis in children?
The pentavalent rotavirus vaccine demonstrates sustained high effectiveness against severe rotavirus gastroenteritis through the second year of life.
Answers are grounded in this paper and cite their sources.
Supports pentavalent rotavirus vaccine use in infants; leaves open need for randomized confirmation of sustained effectiveness.
Fecal specimens from children presenting to Texas Children's Hospital with acute gastroenteritis were tested for the presence of rotavirus. Children were grouped according to vaccination status, and pentavalent rotavirus vaccine effectiveness was calculated. Pentavalent rotavirus vaccine effectiveness against severe rotavirus gastroenteritis was sustained during the first 2 years of the vaccination program. Overall 3-dose effectiveness was 83% to 86%; it was 92% to 93% among children 6 to 11 months of age and 78% to 84% among children ≥12 months of age.
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Boom et al. (2010) conducted an observational in Acute gastroenteritis. Pentavalent rotavirus vaccination vs. Unvaccinated was evaluated on Severe rotavirus gastroenteritis (Vaccine effectiveness 83% to 86%). Pentavalent rotavirus vaccination provided 83% to 86% overall 3-dose effectiveness against severe rotavirus gastroenteritis, with sustained protection during the second year of life.
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