Key result
Experimental renal hypertension in dogs resulted in higher potassium-stimulated ATPase activity of arterial myosin and differences in heavy chain peptide maps compared to normotensive controls.
Population
Dogs with experimental renal (stenosis) hypertension and control normotensive dogs
Comparison
Experimental renal hypertension (stenosis) vs Normotensive control dogs
Design
Preclinical
Authors
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Does not inform hypertension management; leaves open myosin changes in human vascular disease.
Experimental renal hypertension in dogs alters the peptide maps of myosin heavy chains and increases potassium-stimulated ATPase activity in iliac-femoral arteries.
Upadhya et al. (1993) studied Experimental renal hypertension. Experimental renal (stenosis) hypertension vs. Normotensive control dogs was evaluated on Characteristics of arterial myosin (heavy chains, light chains, ATPase activity). Experimental renal hypertension in dogs resulted in higher potassium-stimulated ATPase activity of arterial myosin and differences in heavy chain peptide maps compared to normotensive controls.
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