Key result
Aortic strips from DOCA-hypertensive rats produced less tension than those from control rats at the same preload, accompanied by a decreased volume fraction of smooth muscle.
Why the study?
Does DOCA-induced hypertension alter the functional orientation and force-generating capacity of aortic smooth muscle in rats?
Population
DOCA-hypertensive and normotensive rats
Comparison
Measurement of maximum force-generating capacity… vs Normotensive control rats
Design
Preclinical
Authors
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Hypertension-associated aortic hypocontractility in rats; hypothesis-generating for vascular remodeling and leaves open human relevance.
Does DOCA-induced hypertension alter the functional orientation and force-generating capacity of aortic smooth muscle in rats?
DOCA-hypertensive rats exhibit reduced force-generating capacity in aortic strips, associated with a decreased volume fraction of smooth muscle in the aortic media.
Hansen et al. (2008) studied DOCA-hypertension. DOCA-hypertension vs. Normotensive control rats was evaluated on Maximum force-generating capacity of aortic strips. Aortic strips from DOCA-hypertensive rats produced less tension than those from control rats at the same preload, accompanied by a decreased volume fraction of smooth muscle.