Key result
Clopidogrel administered in the fed state demonstrated equipotent maximum platelet aggregation compared to the fasted state (treatment difference 4.7%; 90% CI 0.9-8.5%).
Why the study?
Does administration with food alter the pharmacodynamics and pharmacokinetics of clopidogrel in healthy men?
Population
72 healthy men
Comparison
Clopidogrel administered with a high-fat or… vs Clopidogrel administered in the fasted state
Design
RCT, randomized crossover, placebo-controlled
Follow-up
5 days
Authors
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Clopidogrel maintains equipotent antiplatelet effect with or without food; supports flexible dosing in healthy volunteers but leaves open patient confirmation.
RCT (n=72)
Crossover
Does administration with food alter the pharmacodynamics and pharmacokinetics of clopidogrel in healthy men?
Mean Difference: 4.7 (95% CI 0.9–8.5)
Absolute Event Rate: 49.7% vs 54%
Administration of clopidogrel with food does not meaningfully alter its antiplatelet efficacy, confirming it can be taken with or without food.
Hurbin et al. (2011) conducted an RCT in Healthy (n=72). Clopidogrel with a high-fat or standard breakfast (fed state) vs. Clopidogrel in the fasted state was evaluated on Maximum platelet aggregation (MPA) induced by ADP 5 µM (MD 4.7%, 95% CI 0.9-8.5). Clopidogrel administered in the fed state demonstrated equipotent maximum platelet aggregation compared to the fasted state (treatment difference 4.7%; 90% CI 0.9-8.5%).
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