Key result
Pressure load increased cardiac oxygen consumption significantly more than volume load (0.0560 vs 0.038 ml O2/beat; P<0.01) in isolated canine hearts despite comparable stroke work.
Why the study?
Does pressure load increase cardiac oxygen consumption more than volume load in isolated canine hearts?
Population
Isolated supported canine hearts
Comparison
Pressure load vs Volume load
Design
Preclinical
Authors
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Supports PVA as key determinant of myocardial energetics; extends isolated-heart observations but leaves clinical translation open.
Does pressure load increase cardiac oxygen consumption more than volume load in isolated canine hearts?
Absolute Event Rate: 0.056% vs 0.038%
p-value: p=<0.01
The study demonstrates that the greater cardiac oxygen consumption under pressure load compared to volume load can be accounted for by the ventricular systolic pressure-volume area (PVA).
Suga et al. (1982) studied Cardiac oxygen consumption under pressure vs volume load. Pressure load vs. Volume load was evaluated on Cardiac oxygen consumption (VO2) (p=<0.01). Pressure load increased cardiac oxygen consumption significantly more than volume load (0.0560 vs 0.038 ml O2/beat; P<0.01) in isolated canine hearts despite comparable stroke work.
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