Time dependence of the oxygen cost of force development during systole in the canine left ventricle.

To determine whether the oxygen cost of force development in the canine left ventricle is constant throughout systole, we inserted fluid-filled Latex balloons into eight isolated canine left ventricles perfused via support dogs. Balloon volumes were varied by a hydraulic servoactuator designed to withdraw preset volumes rapidly (0.5 ml/msec) beginning at a specified ejection pressure. Oxygen consumption was related to force-time integrals for 9-12 different ejections patterns formed by ejecting three or four different volumes from the same end-diastolic volume, each ejection beginning at three different pressures, isovolumic beats with four or five different end-diastolic volumes, including those used for the ejections. The force-time integral vs. oxygen consumption data are nonlinear for ejections that began at low pressures, with oxygen consumption exceeding that predicted from regression lines fitted to the isovolumic data. This difference appeared to peak at relatively low force-time integrals and then curve back to converge with the isovolumic line. This pattern was not evident for ejections that began late in systole. Although these results suggest that the energy required for force development is greater than expected early in systole, they also are consistent with the hypothesis that oxygen consumption is a function only of instantaneous ventricular volume.