Key result
Adrenalectomy prevented proteinuria (12 vs 49 mg/d; P<0.01) and abrogated thrombotic microangiopathy, while aldosterone infusion restored these lesions independent of hypertension.
Population
Salt-loaded, stroke-prone, spontaneously hypertensive rats (SHRSP) drinking saline
Comparison
Adrenalectomy followed by infusion of… vs Sham-operated rats or adrenalectomy alone with…
Design
Preclinical, Rats were assigned to one of four groups
Authors
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Preclinical data link aldosterone to proteinuria and TMA independent of hypertension; hypothesis-generating for human studies, should not change practice.
Absolute Event Rate: 12% vs 49%
p-value: p=<0.01
Aldosterone, independent of hypertension, plays a pivotal role in the development of thrombotic microangiopathy in stroke-prone spontaneously hypertensive rats.
Chander et al. (2003) studied Thrombotic microangiopathy. Adrenalectomy with or without Aldosterone or Angiotensin II infusion vs. Sham operation was evaluated on Proteinuria (p=<0.01). Adrenalectomy prevented proteinuria (12 vs 49 mg/d; P<0.01) and abrogated thrombotic microangiopathy, while aldosterone infusion restored these lesions independent of hypertension.
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