Key result
Perfusion of dog papillary muscles with low sodium chloride, low sodium, or high calcium concentrations produced specific ultrastructural alterations including sarcoplasmic reticulum dilatation and mitochondrial swelling.
Population
Functioning dog papillary muscles
Comparison
Perfusion with isotonic solutions of varying… vs Control muscles perfused with standard solution
Design
Preclinical
Authors
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Ion-induced ultrastructural changes in canine myocardium are hypothesis-generating; should not yet inform clinical ion management.
Variations in perfusate sodium and calcium concentrations produce specific ultrastructural changes in mammalian myocardium, suggesting subcellular loci of specific ion permeability.
Legato et al. (1968) studied this question. Variation in perfusate sodium, calcium, and chloride concentrations vs. Control muscles (normal ionic composition) was evaluated on Subcellular morphology changes (ultrastructural alterations). Perfusion of dog papillary muscles with low sodium chloride, low sodium, or high calcium concentrations produced specific ultrastructural alterations including sarcoplasmic reticulum dilatation and mitochondrial swelling.
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