July 1, 1967Cardiovascular Research

Morphological Changes of Heart Muscle Caused by Successive Perfusion with Calcium-free and Calcium-containing Solutions (Calcium Paradox)

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Why the study?

Does reinstitution of calcium ions after calcium-free perfusion cause morphological and functional damage in isolated rat hearts?

Population

Isolated rat hearts

Design

Preclinical

Authors

AZA. N. E. ZimmermanHôpital Broussais WDWalter DaemsUniversity of Antwerp WHW.C. HülsmannErasmus University Rotterdam

Discussion

Member takes

Implication

May guide experimental myocardial protection protocols; leaves open clinical translation in humans.

Structured PICO

Does reinstitution of calcium ions after calcium-free perfusion cause morphological and functional damage in isolated rat hearts?

Population

Isolated rat hearts

Intervention

Perfusion with a modified Tyrode solution followed by perfusion with a calcium-free perfusate, then reinstitution of calcium ions

Outcome

Morphological changes, contractility, and electrical activitysurrogate

Reinstitution of calcium after calcium-free perfusion causes severe morphological and functional damage to the myocardium, known as the calcium paradox.

Cite This Study

Zimmerman et al. (1967) studied this question.

synapsesocial.com/papers/6a7d1b7a2c71273e4183d78e https://doi.org/10.1093/cvr/1.3.201

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Morphological Changes of Heart Muscle Caused by Successive Perfusion with Calcium-free and Calcium-containing Solutions (Calcium Paradox)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Morphological Changes of Heart Muscle Caused by Successive Perfusion with Calcium-free and Calcium-containing Solutions (Calcium Paradox)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider