Key result
Among men with metabolic syndrome, elevated C-reactive protein was associated with significantly higher pulse wave velocity (1508 vs 1427 cm/s; P<0.01).
Why the study?
Does elevated C-reactive protein augment increased arterial stiffness (measured by pulse wave velocity) in men with metabolic syndrome?
Population
5,752 middle-aged Japanese men (mean age 44+/-10 years)
Comparison
Presence of metabolic syndrome disorders and… vs Absence of metabolic syndrome disorders or…
Design
Cross-sectional
Authors
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May link inflammation to arterial stiffness in metabolic syndrome men; hypothesis-generating and requires prospective confirmation before practice change.
Cross-Sectional (n=5,752)
Does elevated C-reactive protein augment increased arterial stiffness (measured by pulse wave velocity) in men with metabolic syndrome?
Absolute Event Rate: 1508% vs 1427%
p-value: p=<0.01
Elevated C-reactive protein and an increasing number of metabolic syndrome disorders are independently associated with increased arterial stiffness, highlighting a potential pathophysiological mechanism for increased cardiovascular risk in this population.
Tomiyama et al. (2005) conducted a cross-sectional in Metabolic Syndrome (n=5,752). Elevated C-reactive protein vs. Without elevated C-reactive protein was evaluated on Pulse wave velocity (p=<0.01). Among men with metabolic syndrome, elevated C-reactive protein was associated with significantly higher pulse wave velocity (1508 vs 1427 cm/s; P<0.01).
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