Key result
The apolipoprotein E epsilon 4 allele significantly increased the risk of hypertriglyceridemia in obese subjects (OR 3.15; P<0.005).
Why the study?
Does the apolipoprotein E4 allele increase the risk of hypertriglyceridemia in obese subjects?
Population
172 obese French subjects
Comparison
Presence of apolipoprotein E4 (epsilon 4) allele vs Absence of apolipoprotein E4 allele
Design
Cross-sectional
Authors
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ApoE testing not indicated in obese hypertriglyceridemia; leaves open allele influence on lipids pending larger studies.
Cross-Sectional (n=172)
Does the apolipoprotein E4 allele increase the risk of hypertriglyceridemia in obese subjects?
Odds Ratio: 3.15
p-value: p=<0.005
The apolipoprotein E4 allele is associated with a significantly increased risk of hypertriglyceridemia in obese individuals.
Fumeron et al. (1988) conducted a cross-sectional in Obesity and hypertriglyceridemia (n=172). Apolipoprotein E epsilon 4 allele vs. Absence of epsilon 4 allele was evaluated on Hypertriglyceridemia (triglycerides ≥ 200 mg/dl) (OR 3.15, p=<0.005). The apolipoprotein E epsilon 4 allele significantly increased the risk of hypertriglyceridemia in obese subjects (OR 3.15; P<0.005).
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