Association of Fasting Plasma Glucose With Heart Rate Recovery in Healthy Adults
Key result
Impaired fasting glucose was associated with a higher prevalence of abnormal heart rate recovery compared to normal fasting glucose (42% vs. 31%; RR 1.34; 95% CI 1.20-1.50; P<0.0001).
Why the study?
Does elevated fasting plasma glucose increase the risk of abnormal heart rate recovery in healthy adults?
Population
5,190 healthy adults who did not have medically treated diabetes, mean age 45 years, 39% women, enrolled in…
Comparison
Elevated fasting plasma glucose vs Normal fasting plasma glucose
Design
Cohort
Follow-up
12 years
Authors
Discussion
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Member takes
Implication
May signal early autonomic dysfunction in prediabetes; hypothesis-generating and requires prospective trials before clinical adoption.
Study Design
Type
Cohort (n=5,190)
Multicenter
Yes
Structured PICO
Does elevated fasting plasma glucose increase the risk of abnormal heart rate recovery in healthy adults?
P
Population
5,190 healthy adults without medically treated diabetes (mean age 45 years, 39% women) who underwent exercise testing and were followed for 12 years.
E
Exposure
Elevated fasting plasma glucose (impaired fasting glucose or untreated diabetes)
C
Comparator
Normal fasting plasma glucose
O
Outcome
Abnormal heart rate recovery (defined as change from peak heart rate to that after 2 min of recovery ≤ 42 bpm)surrogate
Main Result
Relative Risk: 1.34 (95% CI 1.2–1.5)
Absolute Event Rate: 42% vs 31%
p-value: p=< 0.0001
Fasting plasma glucose is strongly and independently associated with abnormal heart rate recovery (a marker of autonomic dysfunction) even at non-diabetic levels, adding prognostic value for predicting mortality.
Cite This Study
Panzer et al. (2002) conducted a cohort in Healthy adults (n=5,190). Impaired fasting glucose vs. Normal fasting plasma glucose was evaluated on Abnormal heart rate recovery (≤ 42 bpm change after 2 min) (RR 1.34, 95% CI 1.20-1.50, p=< 0.0001). Impaired fasting glucose was associated with a higher prevalence of abnormal heart rate recovery compared to normal fasting glucose (42% vs. 31%; RR 1.34; 95% CI 1.20-1.50; P<0.0001).