Key result
A novel quadripolar LV lead provided programmable configurations with a threshold <2.5 V and no phrenic nerve stimulation in 97% of patients versus 86% with conventional bipolar vectors.
Why the study?
Does a novel quadripolar electrode left ventricular lead improve pacing thresholds and reduce phrenic nerve stimulation compared to conventional bipolar configurations in patients indicated for CRT?
Population
75 patients indicated for cardiac resynchronization therapy (CRT)
Comparison
Quadripolar electrode left ventricular lead and… vs Conventional bipolar configurations
Design
Cohort
Follow-up
1 month
Authors
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May increase optimal LV lead programming success in CRT; extends bipolar comparisons but leaves open need for RCTs.
Observational (n=75)
Yes
Does a novel quadripolar electrode left ventricular lead improve pacing thresholds and reduce phrenic nerve stimulation compared to conventional bipolar configurations in patients indicated for CRT?
Absolute Event Rate: 97% vs 86%
A novel quadripolar left ventricular lead provides increased programming options to successfully manage elevated pacing thresholds and phrenic nerve stimulation compared to conventional bipolar leads.
Sperzel et al. (2011) conducted an observational in Cardiac resynchronization therapy indication (n=75). Quadripolar electrode lead and CRT-D device vs. Conventional bipolar configurations was evaluated on One or more programmable configurations with a threshold < 2.5 V and no phrenic nerve stimulation. A novel quadripolar LV lead provided programmable configurations with a threshold <2.5 V and no phrenic nerve stimulation in 97% of patients versus 86% with conventional bipolar vectors.
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