Key result
Exercising 12 hours prior to a fat-rich meal significantly reduced the postprandial triglyceride AUC score by 33% compared to control (p<0.02), whereas exercising 24 hours prior did not.
Why the study?
Does exercise timing (12 vs 24 hours premeal) reduce postprandial hypertriglyceridemia in hypertriglyceridemic men?
Does exercise timing (12 vs 24 hours premeal) reduce postprandial hypertriglyceridemia in hypertriglyceridemic men?
Effect estimate: 33% lower vs control
p-value: p=< 0.02
An acute bout of exercise 12 hours prior to a fat-rich meal significantly reduces postprandial hypertriglyceridemia in hypertriglyceridemic men, but this effect is diminished if the exercise is performed 24 hours prior.
May blunt postprandial lipemia when performed 12 hours before fat-rich meals; hypothesis-generating and requires confirmation in larger trials.
We investigated the effect of exercise timing on attenuation of postprandial hyper-triglyceridemia (PHTG) in individuals with hypertriglyceridemia (HTG). Subjects were 10 males (TG = 290.1 +/- 28.5 mg/dl). Each subject performed a control trial (Ctr), 12-hr premeal exercise trial (12-hr Pre), and 24-hr premeal exercise trial (24-hr Pre). In each trial, subjects had a fat-rich meal. In the exercise trials they jogged on a treadmill at 60% of their VO2max for 1 hr at a designated time. Blood samples were taken at 0 (immediately before the fat meal), and at 2, 4, 6, 8, and 24 hrs after the meal. The results indicated that plasma TG concentrations in 12-hr Pre were lower than in Ctr and 24-hr Pre (p < 0.03). The area score under the TG concentration curve (TG AUC score) in 12-hr Pre was 37% and 33% lower than in 24-hr Pre and Ctr (p < 0.02), respectively. Insulin concentrations in 12-hr Pre were lower than Ctr and 24-hr Pre (p < 0.001). The plasma nonesterified fatty acid (NEFA) concentration was higher in 12-hr Pre than in both 24-hr Pre and Ctr (p < 0.003). There were no trial differences in both HDLtot-Ch and HDL2-Ch. These results suggest that exercising 12 hrs prior to a fat-meal intake significantly reduces PHTG response whereas exercising 24 hrs prior to the meal does not attenuate PHTG in hypertriglyceridemic men. The effect of an acute exercise bout on PHTG lowering may be short-lived and diminished by 24 hrs.
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Zhang et al. (2004) studied Hypertriglyceridemia (n=10). 12-hour premeal exercise vs. Control trial (no exercise) and 24-hour premeal exercise was evaluated on Triglyceride area under the concentration curve (TG AUC score) (33% lower vs control, p=< 0.02). Exercising 12 hours prior to a fat-rich meal significantly reduced the postprandial triglyceride AUC score by 33% compared to control (p<0.02), whereas exercising 24 hours prior did not.
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