Key result
Prediabetes in obese youth was significantly associated with increased internal carotid intima-media thickness and lower brachial distensibility compared with normal glucose tolerance (P < .05).
Why the study?
Is prediabetes associated with increased arterial thickness and stiffness in obese youth compared to those with normal glucose tolerance?
Population
241 obese youth. Prediabetes diagnosed by fasting blood glucose 100-125 mg/dL, 2-hour OGTT 140-199 mg/dL, or…
Comparison
Prediabetes vs Normal glucose tolerance
Design
Cross-sectional
Authors
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Adolescent prediabetes may associate with early arterial changes; hypothesis-generating and requires prospective studies before clinical adoption.
Cross-Sectional (n=241)
Is prediabetes associated with increased arterial thickness and stiffness in obese youth compared to those with normal glucose tolerance?
p-value: p=< .05
Prediabetes in obese youth is associated with early markers of cardiovascular disease, specifically increased arterial thickness and stiffness.
Shah et al. (2014) conducted a cross-sectional in Prediabetes in obese youth (n=241). Prediabetes vs. Normal glucose tolerance was evaluated on Arterial thickness and stiffness (carotid IMT, augmentation index, pulse wave velocity, and brachial distensibility) (p=< .05). Prediabetes in obese youth was significantly associated with increased internal carotid intima-media thickness and lower brachial distensibility compared with normal glucose tolerance (P < .05).
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