Key result
Kallikrein was concentrated in the plasma-membrane fraction of rat kidney cortex, whereas kininase II was localized in the brush-border membrane.
Population
Homogenized rat kidney cortex
Design
Preclinical
Authors
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Suggests distinct rat tubular origins for kallikrein versus kininase II; leaves open their coordinated role in human renal physiology.
The study demonstrates that renal kallikrein is localized to the plasma membrane (likely distal tubules) while kininase II is localized to the brush-border membrane (proximal tubules) in rat kidneys.
Ward et al. (1975) studied this question. Kallikrein was concentrated in the plasma-membrane fraction of rat kidney cortex, whereas kininase II was localized in the brush-border membrane.
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