Key result
A-type potassium currents in murine antral smooth muscle cells, likely due to Kv4 channels, are blocked by 4-AP and flecainide and contribute to maintaining negative resting membrane potentials.
A-type potassium currents, likely mediated by Kv4 channels, are present in murine gastric antrum smooth muscle cells and contribute to maintaining negative resting membrane potentials.
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May influence subthreshold excitability in gastric smooth muscle; extends ion channel mapping in phasic tissues but requires in vivo validation.
Amberg et al. (2002) studied this question. 4-aminopyridine (4-AP) and flecainide was evaluated on Characterization of A-type potassium currents. A-type potassium currents in murine antral smooth muscle cells, likely due to Kv4 channels, are blocked by 4-AP and flecainide and contribute to maintaining negative resting membrane potentials.
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