Why the study?
Does pharmacological blockade of I(A) alter action potential waveform and firing activity in rat presympathetic PVN neurones?
Population
Rat presympathetic paraventricular nucleus (PVN) neurones innervating the rostral ventrolateral medulla (RVLM)
Comparison
Pharmacological blockade of A-type potassium… vs Unblocked state (baseline)
Design
Preclinical
Authors
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I(A) blockade modulates rat PVN excitability; leaves open translation to human sympathetic regulation or cardiovascular disease.
Does pharmacological blockade of I(A) alter action potential waveform and firing activity in rat presympathetic PVN neurones?
A-type potassium currents actively modulate action potential waveform and firing activity in rat presympathetic PVN neurones, serving as an important intrinsic mechanism controlling neuronal excitability.
Sonner et al. (2007) studied this question.
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