Key result
A 3D analytical model of O2 diffusion in heavily working red muscle showed that fiber PO2 profiles are essentially flat, with major PO2 gradients located in the perierythrocytic region.
Population
Heavily working red muscle (three-dimensional analytical model)
Design
Preclinical
Authors
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Refines muscle O2 transport models; leaves open in vivo validation before revising physiological assumptions.
This analytical model demonstrates that the major PO2 gradients in heavily working red muscle are located in the perierythrocytic region, without requiring a specialized anatomical pericapillary barrier.
Groebe et al. (1990) studied this question. Three-dimensional analytical model of O2 diffusion was evaluated on PO2 gradients and O2 supply. A 3D analytical model of O2 diffusion in heavily working red muscle showed that fiber PO2 profiles are essentially flat, with major PO2 gradients located in the perierythrocytic region.
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