Key result
Frequency domain T-wave alternans showed marked diurnal variation (p<0.0001) and was independently affected by heart rate (β = 0.461, p = 0.001) in subjects without structural heart disease.
Population
47 subjects without significant structural heart disease
Design
Cross-sectional
Follow-up
24 hours
Authors
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Diurnal TWA variation may link to HR or autonomic tone; hypothesis-generating for SCD risk stratification in patients without structural heart disease.
Observational (n=47)
p-value: p=< 0.0001
In subjects without structural heart disease, T-wave alternans exhibits significant diurnal variation that is strongly influenced by heart rate.
Hashimoto et al. (2018) conducted an observational in Without significant structural heart disease (n=47). Time of day and heart rate was evaluated on Diurnal variation of frequency domain T-wave alternans (p=< 0.0001). Frequency domain T-wave alternans showed marked diurnal variation (p<0.0001) and was independently affected by heart rate (β = 0.461, p = 0.001) in subjects without structural heart disease.
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