Effect of endothelin antagonists on the responses to prostanoid endothelium‐derived contracting factor
Key result
Bosentan and PD147953 reduced acetylcholine-induced, EDCF-mediated contractions in rat aorta from 24% to 8% (P<0.01) and 14% (P<0.05) of KCl contractions, respectively.
Authors
Discussion
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Implication
Endothelin antagonists may modulate EDCF in vitro; leaves open any clinical relevance pending in vivo confirmation.
PICO
I
Intervention / Comparator
Endothelin antagonists (bosentan and PD147953) vs L-NAME alone
O
Primary Outcome
Acetylcholine-induced contraction (as % of KCl contraction), p=<0.01
Main Result
Absolute Event Rate: 8% vs 24%
p-value: p=<0.01
Cite This Study
Moreau et al. (1996) studied this question. Endothelin antagonists (bosentan and PD147953) vs. L-NAME alone was evaluated on Acetylcholine-induced contraction (as % of KCl contraction) (p=<0.01). Bosentan and PD147953 reduced acetylcholine-induced, EDCF-mediated contractions in rat aorta from 24% to 8% (P<0.01) and 14% (P<0.05) of KCl contractions, respectively.