Why the study?
Does bosentan prevent endothelin-1-induced myocardial ischaemia and oedema in rats?
Population
Anaesthetized and conscious chronically catheterized rats
Comparison
Bosentan (10 mg kg-1, i.v.) pretreatment vs Endothelin-1 alone and ETA receptor-selective…
Design
Preclinical
Follow-up
up to 30 minutes post-injection
Authors
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Bosentan may attenuate ET-1 ischemia in rats; leaves open translation to human myocardial disease.
Does bosentan prevent endothelin-1-induced myocardial ischaemia and oedema in rats?
Bosentan effectively inhibits endothelin-1-induced myocardial ischemia and edema in a rat model, suggesting potential therapeutic value for ischemic myocardial diseases.
Filep et al. (1995) studied this question.
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