Characterization of receptors mediating vascular responses to endothelin‐1 in the conscious rat
Population
Conscious rats
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Differential ETA/ETB mediation of ET-1 effects shown in rats; leaves open translation to human endothelin-targeted therapies.
Structured PICO
P
Population
Conscious rats
I
Intervention
Endothelin-1 (1 nmol kg-1 i.v.) and IRL 1620 (0.1-2 micro mol kg-1 i.v.) with antagonists bosentan (1-20 mg kg-1 i.v.) or FR 139317 (2.5 mg kg-1 i.v.)
O
Outcome
Changes in mean arterial blood pressure (MABP), heart rate, and vascular permeability (albumin extravasation)surrogate
ETA and ETB receptors differentially mediate the pressor, depressor, and vascular permeability effects of endothelin-1 in conscious rats.
Cite This Study
Filep et al. (1994) studied this question.