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July 1, 1994British Journal of PharmacologyOpen Access

Effects of bosentan (Ro 47–0203), an ETA‐, ETB‐receptor antagonist, on regional haemodynamic responses to endothelins in conscious rats

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Population

Conscious Long Evans rats (n=8 in main group, n=7 in separate group)

Comparison

Bosentan (Ro 47-0203) 30 mg kg-1 vs Absence of bosentan

Design

Preclinical

Authors

SGSheila M. GardinerUniversity of NottinghamPKP.A. KempAnalytical Engineering (United States)JMJ E MarchUniversity of Nottingham

Discussion

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Implication

Does not support clinical use of bosentan; leaves open translation of dual ETA/ETB blockade to human cardiovascular research.

Structured PICO

P
Population
Conscious Long Evans rats (n=8 in main group, n=7 in separate group)
I
Intervention
Bosentan (Ro 47-0203) 30 mg kg-1
C
Comparator
Absence of bosentan
O
Outcome
Regional haemodynamic responses to endothelin (ET)-1, -2 and -3 and big ET-1surrogate

Bosentan effectively antagonizes the major haemodynamic effects of endothelins in conscious rats, confirming its role as a mixed ETA/ETB receptor antagonist.

Cite This Study

Gardiner et al. (1994) studied this question.

synapsesocial.com/papers/6a815e8fadfa6baaaee1cf5ehttps://doi.org/10.1111/j.1476-5381.1994.tb13153.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regional haemodynamic effects of endothelin‐1 and endothelin‐3 in conscious Long Evans and Brattleboro rats1990 · 59 citations
  2. 2Discrimination between ET<sub>A</sub>‐ and ET<sub>B</sub>‐receptor‐mediated effects of endothelin‐1 and [Ala<sup>1,3,11,15</sup>]endothelin‐1 by BQ‐123 in the anaesthetized rat1992 · 93 citations
  3. 3Regional hemodynamic effects of endothelin-2 and sarafotoxin-S6b in conscious rats1990 · 16 citations
  4. 4The effects of phosphoramidon on the regional haemodynamic responses to human proendothelin [1–38] in conscious rats1991 · 41 citations