February 26, 2015Angiology
Increased Platelet to Lymphocyte Ratio is Related to Slow Coronary Flow
Key result
Higher platelet to lymphocyte ratio was significantly and independently associated with the presence of slow coronary flow (OR 1.014, P < .001).
Why the study?
Is higher platelet to lymphocyte ratio associated with the presence of slow coronary flow in patients with angiographically normal coronary arteries?
Population
514 patients with angiographically normal coronary arteries (n=221 with slow coronary flow, n=293 controls)
Comparison
Platelet to lymphocyte ratio (PLR) assessment vs Patients with normal coronary flow (control group)
Design
Cohort
Authors
Discussion
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Member takes
Implication
May support PLR for SCF identification; leaves open prognostic value and need for prospective validation.
Study Design
Type
Case-Control (n=514)
Structured PICO
Is higher platelet to lymphocyte ratio associated with the presence of slow coronary flow in patients with angiographically normal coronary arteries?
P
Population
514 patients with angiographically normal coronary arteries, including 221 with slow coronary flow and 293 controls.
E
Exposure
Platelet to lymphocyte ratio (PLR) assessment
C
Comparator
Patients with normal coronary flow (control group)
O
Outcome
Presence of slow coronary flow (SCF) based on thrombolysis in myocardial infarction frame counts (TFC)surrogate
Main Result
Odds Ratio: 1.014
p-value: p=<.001
Higher platelet to lymphocyte ratio is independently associated with slow coronary flow and correlates with systemic inflammation markers like CRP.
Cite This Study
Akboğa et al. (2015) conducted a case-control in Slow coronary flow (n=514). Platelet to lymphocyte ratio (PLR) vs. Control group was evaluated on Presence of slow coronary flow (OR 1.014, p=<.001). Higher platelet to lymphocyte ratio was significantly and independently associated with the presence of slow coronary flow (OR 1.014, P < .001).