Key result
Dexmedetomidine premedication provided better perioperative hemodynamic stability and reduced the requirement for rescue antihypertensive drugs to 0% compared to 17% with midazolam in hypertensive patients (p=0.007).
Why the study?
Does dexmedetomidine premedication improve perioperative hemodynamic stability compared to midazolam in normotensive and hypertensive female patients undergoing myomectomies or hysterectomies?
Population
140 female, normotensive or hypertensive patients undergoing myomectomies or hysterectomies.
Comparison
Dexmedetomidine 0.5 μg/kg via intravenous… vs Midazolam 0.025 μg/kg via intravenous infusion…
Design
RCT, Randomly enrolled into subgroups
Follow-up
Perioperative period (up to 5 minutes post-extubation)
Authors
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Dexmedetomidine may stabilize perioperative hemodynamics better than midazolam in hypertensives; leaves open need for larger confirmatory trials.
RCT (n=140)
Double-blind
Computer program
No
Does dexmedetomidine premedication improve perioperative hemodynamic stability compared to midazolam in normotensive and hypertensive female patients undergoing myomectomies or hysterectomies?
Dexmedetomidine premedication provides superior perioperative hemodynamic stability and reduces the need for intraoperative antihypertensive medications compared to midazolam in hypertensive women undergoing gynecologic surgery.
Sezen et al. (2014) conducted an RCT in Hypertension (n=140). Dexmedetomidine vs. Midazolam (0.025 μg.kg−1 IV infusion) was evaluated on Perioperative hemodynamic parameters (SBP, DBP, MBP, HR). Dexmedetomidine premedication provided better perioperative hemodynamic stability and reduced the requirement for rescue antihypertensive drugs to 0% compared to 17% with midazolam in hypertensive patients (p=0.007).
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