Oral administration of olive leaf extract (EFLA 943) at 100 mg/kg prevented L-NAME induced blood pressure rise and normalized blood pressure in previously hypertensive rats.
Does oral olive leaf extract lower blood pressure in L-NAME induced hypertensive rats?
Olive leaf extract (EFLA 943) demonstrates dose-dependent antihypertensive effects in a rat model of L-NAME induced hypertension.
A specially prepared olive leaf extract (EFLA 943) has been tested for its blood pressure lowering activity in rats rendered hypertensive by daily oral doses of L-NAME (NG-nitro-L-arginine methyl ester, 50 mg/kg) for at least 4 weeks. Oral administration of the extract at different dose levels at the same time as L-NAME for a period of 8 weeks showed a dose dependent prophylactic effect against the rise in blood pressure induced by L-NAME, best effects being induced by a dose of 100 mg/kg of the extract. In rats previously rendered hypertensive by L-NAME for 6 weeks and then treated with that dose of the extract for a further 6 weeks without discontinuation of L-NAME, normalisation of the blood pressure was observed. The findings confirm previous reports on the hypotensive effects of olive leaf. The special extract, EFLA 943, was shown to give consistent results with little individual variability. The antihypertensive effect of the extract may be related to a variety of factors involving reversal of vascular changes involved in the L-NAME induced hypertension.
Khayyal et al. (Mon,) conducted a other in L-NAME induced hypertension. Olive leaf extract (EFLA 943) vs. L-NAME alone was evaluated on Blood pressure. Oral administration of olive leaf extract (EFLA 943) at 100 mg/kg prevented L-NAME induced blood pressure rise and normalized blood pressure in previously hypertensive rats.