Key result
Oral administration of olive leaf extract (EFLA 943) at 100 mg/kg prevented L-NAME induced blood pressure rise and normalized blood pressure in previously hypertensive rats.
Why the study?
Does oral olive leaf extract lower blood pressure in L-NAME induced hypertensive rats?
Population
Rats rendered hypertensive by daily oral doses of L-NAME for at least 4 to 6 weeks
Design
Preclinical
Follow-up
6 to 8 weeks
Authors
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Should not change practice; leaves open antihypertensive effects of olive leaf extract for human trials.
Does oral olive leaf extract lower blood pressure in L-NAME induced hypertensive rats?
Olive leaf extract (EFLA 943) demonstrates dose-dependent antihypertensive effects in a rat model of L-NAME induced hypertension.
Khayyal et al. (2011) studied L-NAME induced hypertension. Olive leaf extract (EFLA 943) vs. L-NAME alone was evaluated on Blood pressure. Oral administration of olive leaf extract (EFLA 943) at 100 mg/kg prevented L-NAME induced blood pressure rise and normalized blood pressure in previously hypertensive rats.
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