Key result
An 8-week calorie restriction program in mildly obese women demonstrated that changes in thermoregulatory sympathetic function significantly correlated with waist circumference reduction (r = -0.53, P < 0.01).
Why the study?
Does an 8-week 1,200-kcal daily diet improve anthropometric parameters and how does it correlate with thermoregulatory sympathetic nervous system activity in mildly obese Japanese women?
Does an 8-week 1,200-kcal daily diet improve anthropometric parameters and how does it correlate with thermoregulatory sympathetic nervous system activity in mildly obese Japanese women?
Effect estimate: r = -0.53
p-value: p=< 0.01
In mildly obese women, an 8-week calorie restriction diet reduces waist circumference and body mass, with changes correlating to thermoregulatory sympathetic activity.
Diet-induced sympathovagal shifts may link to waist reduction in obese women; leaves open causal metabolic benefits in prospective trials.
The present study is designed to investigate how and to what extent sympathovagal behavior in a balanced low-calorie diet relates to favorable changes of body mass, waist circumference, and/or metabolic risk factors. The study involved 28 mildly obese women without clinical complications, who underwent an 8-week calorie restriction program using a 1,200-kcal daily diet with an adequate nutrient content; including two regular meals, and one formula meal replacement. All subjects were examined before and after the dietary intervention. We measured anthropometric parameters, blood pressure, and biochemical blood profiles for lipid metabolism. Autonomic nervous system activity was evaluated by heart rate variability power spectral analysis. The dietary intervention induced moderate, but significant reduction of waist circumference (-5.3% +/- 0.8%), body fat percentage (-5.8% +/- 0.8%), and body mass (-6.6% +/- 0.5%). Linear regression analysis showed that Deltavery low frequency (VLF) power reflecting energy metabolic- and thermoregulatory sympathetic function significantly correlated to Deltawaist circumference (r = -0.53, P < 0.01), Deltabody fat percentage (r = -0.39, P < 0.05), Deltabody mass (r = -0.43, P < 0.05), DeltaHDL-cholesterol/total cholesterol ratio (HDL-C/TC) (r = 0.62, P < 0.001), and Deltanonesterified fatty acids (NEFA) (r = 0.56, P < 0.01). A stepwise multiple regression analysis additionally revealed that Deltawaist circumference (P = 0.024), DeltaHDL-C/TC (P = 0.013), and DeltaNEFA (P = 0.016) were significant and independent factors, which contributing to the variance in DeltaVLF power (r(2) = 0.61). Although causes and consequences of obesity continue to elude researchers, the present study indicates that thermoregulatory sympathetic activity relates to moderate waist-circumference reduction together with favorable changes of blood lipid profiles after short-term dietary modification in mildly obese women.
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Fujibayashi et al. (2009) studied Mild obesity (n=28). Calorie restriction program was evaluated on Correlation between change in very low frequency (VLF) power and change in waist circumference (r = -0.53, p=< 0.01). An 8-week calorie restriction program in mildly obese women demonstrated that changes in thermoregulatory sympathetic function significantly correlated with waist circumference reduction (r = -0.53, P < 0.01).
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