Key result
Heterologously expressed human serotonin 1A receptors in rat atrial myocytes successfully coupled to and activated the endogenous muscarinic K+ channels.
Heterologously expressed human serotonin 1A receptors couple directly to endogenous muscarinic K+ channels via G proteins in rat atrial myocytes, demonstrating a conserved signaling pathway.
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Provides manipulable in vitro model for receptor-G protein-K+ coupling; leaves open physiological relevance in intact heart.
Karschin et al. (1991) studied this question. Recombinant vaccinia virus expressing human serotonin 1A receptors vs. Noninfected atrial cells was evaluated on Activation of inwardly rectifying K+ conductance. Heterologously expressed human serotonin 1A receptors in rat atrial myocytes successfully coupled to and activated the endogenous muscarinic K+ channels.
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