Key result
In transgenic mice, J1ICD-mediated Notch inhibition diminished neonatal cardiomyocyte proliferation, promoted maturation, and blunted the hypertrophic response in the stressed adult heart.
J1ICD-mediated Notch inhibition reveals a novel pathway regulating cardiac homeostasis, modulating both physiological maturation and pathological hypertrophy.
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Does not inform clinical decisions; leaves open non-canonical J1ICD effects on adult cardiac homeostasis.
Metrich et al. (2015) studied Cardiac homeostasis and hypertrophy. J1ICD (Jagged1 intracellular domain) activation was evaluated on Cardiomyocyte proliferation, maturation, and hypertrophic response. In transgenic mice, J1ICD-mediated Notch inhibition diminished neonatal cardiomyocyte proliferation, promoted maturation, and blunted the hypertrophic response in the stressed adult heart.
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