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November 23, 2017Cardiovascular ResearchOpen Access

Reversible Notch1 acetylation tunes proliferative signalling in cardiomyocytes

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Population

Neonatal rat cardiomyocytes and neonatal mice (apical resection model)

Design

Preclinical

Authors

CCChiara CollesiGFGiulia FelicianISIlaria Secco

Discussion

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Overview

Notch1 acetylation may drive neonatal cardiomyocyte regeneration; leaves open therapeutic targeting in adult human hearts.

Structured PICO

P
Population
Neonatal rat cardiomyocytes and neonatal mice (apical resection model)
I
Intervention
Viral vector-mediated expression of a constitutively acetylated fusion protein between Notch1 and the acetyltransferase domain of p300
O
Outcome
Cardiomyocyte proliferation and heart regeneration after apical resectionsurrogate

Reversible acetylation of Notch1 is a novel mechanism that modulates its signaling and enhances the proliferative and regenerative potential of neonatal cardiomyocytes.

Cite This Study

Collesi et al. (2017) studied this question.

synapsesocial.com/papers/6a83b04020cfb2932ffe1adahttps://doi.org/10.1093/cvr/cvx228
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Activation of Notch signaling in cardiomyocytes during post-infarction remodeling2010 · 48 citations
  2. 2A Dynamic Notch Injury Response Activates Epicardium and Contributes to Fibrosis Repair2010 · 140 citations
  3. 3Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy2002 · 1,534 citations
  4. 4Activation of Notch signaling pathway precedes heart regeneration in zebrafish2003 · 343 citations
  5. 5Notch Signaling in Cardiac Development2008 · 257 citations